Τίτλος:
Comparison of raloxifene and atorvastatin effects on serum lipids
composition of healthy post-menopausal women
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study was to evaluate the effects of the selective
oestrogen receptor modulator, raloxifene, and those of statin,
atorvastatin, in reducing the cardiovascular risks associated with the
post-menopausal status. A detailed study of serum lipid concentrations
was performed in four groups of post-menopausal women receiving either
placebo, raloxifene or atorvastatin alone or their combination for the
period of three months.
Group A (raloxifene) showed significant decrease in total cholesterol
levels (P < 0.05) and an increase in phospholipids concentration (P <
0.05), followed by a marked reduction in low-density lipoprotein
cholesterol (LDL-C) levels (P < 0.01) and ApoB amounts (P < 0.001).
Additionally, ApoA-I concentration was significantly increased (P <
0.01).
Group B (atorvastatin) presented decreased cholesterol (P < 0.05) and
triglycerides levels (P < 0.01), followed by elevated high-density
lipoprotein cholesterol (HDL-C) concentration (P < 0.05) and low LDL-C
amounts (P < 0.001). ApoA-I was significantly increased (P < 0.001)
whereas ApoB was reduced (P < 0.001).
The combined treatment in Group C (raloxifene and atorvastatin) showed
significant changes in the majority of serum lipids. In particular,
total cholesterol was reduced (P < 0.001), as well as triglycerides (P <
0.001) levels. Phospholipids were raised (P < 0.01) whereas LDL-C was
reduced ( P < 0.001) as was ApoB ( P < 0.001). Furthermore, ApoA-I was
elevated ( P < 0.001). A further attempt to evaluate each treatment
group was performed and the significance of these results is discussed.
Συγγραφείς:
Piperi, C
Kalofoutis, C
Lagogianni, I
Troupis, G and
Kalofoutis, A
Περιοδικό:
Molecular and Cellular Biochemistry
Λέξεις-κλειδιά:
raloxifene; atorvastatin; serum lipids; cholesterol; HDL; LDL;
phospholipids; triglycerides; post-menopausal women
DOI:
10.1023/B:MCBI.0000028739.10079.0b
