Περίληψη:
The hypothesis of the existence of one or more schizophrenia
susceptibility loci on chromosome 22q is supported by reports of genetic
linkage and association, meta-analyses of linkage, and the observation
of elevated risk for psychosis in people with velocardiofacial syndrome,
caused by 22q11 microdeletions. We tested this hypothesis by evaluating
10 microsatellite markers spanning 22q in a multicenter sample of 779
pedigrees. We also incorporated age at onset and sex into the analysis
as covariates. No significant evidence for linkage to schizophrenia or
for linkage associated with earlier age at onset, gender, or
heterogeneity across sites was observed. We interpret these findings to
mean that the population-wide effects of putative 22q schizophrenia
susceptibility loci are too weak to detect with linkage analysis even in
large samples.
Συγγραφείς:
Mowry, BJ
Holmans, PA
Pulver, AE
Gejman, PV
Riley, B and
Williams, NM
Laurent, C
Schwab, SG
Wildenauer, DB and
Bauche, S
Owen, MJ
Wormley, B
Sanders, AR
Nestadt, G and
Liang, KY
Duan, J
Ribble, R
Norton, N
Soubigou, S and
Maier, W
Ewen-White, KR
deMarchi, N
Carpenter, B
Walsh,
D
Williams, H
Jay, M
Albus, M
Nertney, DA and
Papadimitriou, G
O'Neill, A
O'Donovan, MC
Deleuze, JF and
Lerer, FB
Dikeos, D
Kendler, KS
Mallet, J
Silverman, JM
and Crowe, RR
Levinson, DF
Λέξεις-κλειδιά:
linkage (genetics); chromosomes, human, pair 22; schizophrenia;
genetics, molecular; genetics, medical
