Τίτλος:
Mutational analysis of BRAF in gallbladder carcinomas in association
with K-ras and p53 mutations and microsatellite instability
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Little is known about the genetic changes involved in the
pathogenesis of gallbladder cancer. The aim of this study was to examine
the presence of mutations in exon 15 of the B-raf gene to investigate
its role in gallbladder carcinogenesis. Materials and methods. We
examined the mutational status in exon 15 of B-raf gene in 21
gallbladder carcinoma specimens and investigated its association with
the presence of K-ras and p53 alterations, microsatellite instability
and the clinicopathological features of tumors. Results. B-raf mutations
were observed in 7 of 21 (33%) gallbladder carcinomas examined, and all
were located at the hot spot codon 599 of exon 15. K-ras and B-raf
mutations were never in the same specimens. Conclusions. B-raf gene
mutations seem to be a quite common event in gallbladder carcinomas,
implying that B-raf may play an important role in the pathogenesis of
this tumor.
Συγγραφείς:
Saetta, AA
Papanastasiou, P
Michalopoulos, NV
Gigelou, F and
Korkolopoulou, P
Bei, T
Patsouris, E
Περιοδικό:
Virchows Archiv
Λέξεις-κλειδιά:
B-raf; gallbladder cancer; K-ras
DOI:
10.1007/s00428-004-1046-9
