Περίληψη:
The evidence for anthropometric factors influencing breast cancer risk
is accumulating, but uncertainties remain concerning the role of fat
distribution and potential effect modifiers. We used data from 73,542
premenopausal and 103,344 postmenopausal women from 9 European
countries, taking part in the EPIC study. RRs from Cox regression models
were calculated, using measured height, weight, BMI and waist and hip
circumferences; categorized by cohort wide quintiles; and expressed as
continuous variables, adjusted for study center, age and other risk
factors. During 4.7 years of follow-up, 1,879 incident invasive breast
cancers were identified. In postmenopausal women, current HRT modified
the body size-breast cancer association. Among nonusers, weight, BMI and
hip circumference were positively associated with breast cancer risk
(all P-trend less than or equal to 0.002); obese women (BMI > 30) had a
31% excess risk compared to women with BMI < 25. Among HRT users, body
measures were inversely but nonsignificantly associated with breast
cancer. Excess breast cancer risk with HRT was particularly evident
among lean women. Pooled RRs per height increment of 5 cm were 1.05
(95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in
postmenopausal women. Among premenopausal women, hip circumference was
the only other measure significantly related to breast cancer (P-trend =
0.03), after accounting for BMI. In postmenopausal women not taking
exogenous hormones, general obesity is a significant predictor of breast
cancer, while abdominal fat assessed as waist-hip ratio or waist
circumference was not related to excess risk when adjusted for BMI.
Among premenopausal women, weight and BMI showed nonsignificant inverse
associations with breast cancer. (C) 2004 Wiley-Liss, Inc.
Συγγραφείς:
Lahmann, PH
Hoffmann, K
Allen, N
Van Gils, CH
Khaw, KT
and Tehard, B
Berrino, F
Tjonneland, A
Bigaard, J
Olsen,
A
Overvad, K
Clavel-Chapelon, F
Nagel, G
Boeing, H and
Trichopoulos, D
Economou, G
Bellos, G
Palli, D
Tumino, R
and Panico, S
Amiano, P
Pera, G
Quiros, JR
Martinez, C
and Tormo, MJ
Wirfalt, E
Berglund, G
Hallmans, G
Key, TJ
and Reeves, G
Bingham, S
Norat, T
Biessy, C
Kaaks, R and
Riboli, E
