Τίτλος:
Distribution of serogroups and genotypes among disease-associated and
carried isolates of Neisseria meningitidis from the Czech Republic,
Greece, and Norway
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The distribution of serogroups and multilocus sequence types (STs) in
collections of disease-associated and carried meningococci from the
period 1991 to 2000 in three European countries (the Czech Republic,
Greece, and Norway) was investigated. A total of 314 patient isolates
and 353 isolates from asymptomatic carriers were characterized. The
frequency distributions of serogroups and clone complexes differed among
countries and between disease and carrier isolate collections. Highly
significant differentiation was seen at each housekeeping locus. A
marked positive association of serogroup C with disease was evidenced.
The ST-11 complex was strongly positively associated with disease;
associations for other clone complexes were weaker. The genetic
diversity of the clone complexes differed. A single ST dominated the
ST-11 clone complex, while the ST-41/44 complex exhibited greater levels
of diversity. These data robustly demonstrated differences in the
distribution of meningococcal genotypes in disease and carrier isolates
and among countries. Further, they indicated that differences in
genotype diversity and pathogenicity exist between meningococcal clone
complexes.
Συγγραφείς:
Yazdankhah, SP
Kriz, P
Tzanakaki, G
Kremastinou, J and
Kalmusova, J
Musilek, M
Alvestad, T
Jolley, KA
Wilson,
DJ
McCarthy, ND
Caugant, DA
Maiden, MCJ
Περιοδικό:
Journal of Clinical Microbiology
Εκδότης:
AMER SOC MICROBIOLOGY
DOI:
10.1128/JCM.42.11.5146-5153.2004
