Τίτλος:
Hemodynamic effects of Levosimendan added to Dobutamine in patients with
decompensated advanced heart failure refractory to Dobutamine alone
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A 24-hour infusion of levosimendan was added to dobutamine in 18
patients (aged 63 +/- 9 years) hospitalized for management of
decompensated New York Heart Association functional class IV heart
failure refractory to a continuous 24-hour infusion of dobutamine (10
mug/kg/min) and furosemide (10 mg/hour); the primary study end point was
a greater than or equal to40% increase in cardiac index and a greater
than or equal to25% decrease in pulmonary capillary wedge pressure
compared with pretreatment measurements. The primary end point was
reached in none of the patients treated with dobutamine alone versus 7
patients (39%) treated with levosimendan and dobutamine combined (p =
0.008), whereas at 24 hours, the combined treatment was associated with
a 0.76 +/- 0.78 L/min/m(2) (p = 0.001) mean increase in cardiac index
and a 6.4 +/- 7.3 mm Hg (p = 0.002) mean decrease in pulmonary capillary
wedge pressure compared with measurements obtained after 24 hours of
dobutamine infusion alone. Symptoms were alleviated in, all patients,
and all but 3 were discharged from the hospital. (C) 2004 by Excerpta
Medica, Inc.
Συγγραφείς:
Nanas, JN
Papazoglou, PP
Terrovitis, JV
Kanakakis, J and
Dalianis, A
Tsolakis, E
Tsagalou, EP
Agrios, N and
Christodoulou, K
Anastasiou-Nana, MI
Περιοδικό:
AMERICAN JOURNAL OF CARDIOLOGY
Εκδότης:
Excerpta Medica Inc.
DOI:
10.1016/j.amjcard.2004.07.128
