Τίτλος:
Levels of soluble forms of ICAM and VCAM in patients with
myelodysplastic syndromes and their prognostic significance
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study was to assess circulating soluble intercellular
adhesion molecule-1 (sICAM-1). soluble vascular cell adhesion molecule-1
(sVCAM-1). and interleukin-1beta (IL-1beta) in myelodysplastic syndromes
(MDS) in order to evaluate their clinical significance. Seventy patients
with untreated NOS [21 refractory anemia (RA), nine RA with ringed
sideroblasts (RARS). 17 RA with excess of blasts (R-AM). 11 RAEB in
transformation (RAEBt). and 12 chronic myelomonocytic leukemia (CMML)]
were included in this study, Serum levels of sICAM, sVCAM, and IL-1beta
were determined at diagnosis using commercially available immunoassays.
In addition. 15 healthy, volunteers were studied as a control group.
sICAM, sVCAM, and Il-1beta serum levels were significantly higher in MDS
patients in comparison with the control group (P < 0.001). Patients with
CMML showed the highest sICAM. sVCAM. and IL-1beta levels in comparison
with other MDS-related subtypes. Furthermore significantly elevated
levels of the studied parameters were detected in high-risk MDS patients
(RAEB, RAEB-t, and CMML) in comparison with low-risk MDS (RA and RARS).
IL-1beta was strongly correlated both to sICAM and sVCAM. In conclusion
we have provided evidence that increased sICAM and sVCAM serum levels
are related to MDS severity.
Συγγραφείς:
Passam, FH
Tsirakis, G
Boula, A
Fragou, A
Consolas, I
and Alegakis, A
Kyriakou, DS
Alexandrakis, MG
Περιοδικό:
CLINICAL AND LABORATORY HAEMATOLOGY
Λέξεις-κλειδιά:
cell adhesion molecules; myelodysplastic syndrome; IL-1 beta; sICAM;
sVCAM
DOI:
10.1111/j.1365-2257.2004.00640.x
