Τίτλος:
Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR
spectroscopy study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Patients with obstructive sleep apnoea syndrome frequently have
cognitive deficits, especially related to executive functions, which
cannot be fully explained by daytime sleepiness and are partial
irreversible after nasal continuous positive airway pressure treatment.
The causal mechanism of these cognitive deficits is not yet known, but
it has been proposed that they are associated with chemical and
structural brain cell injury. The aim of this study was to investigate
brain metabolism in patients with sleep apnoea syndrome.
Twenty-two patients with severe sleep apnoea and 10 healthy volunteers
of comparable age were studied using single voxel proton magnetic
resonance spectroscopy. Magnetic resonance spectra were obtained from
prefrontal cortex, parieto-occipital and frontal periventricular white
matter. N-acetylaspartate-to-creatine and choline-to-creatine ratios
were significantly lower in the frontal white matter of obstructive
sleep apnoea patients when compared to controls. Absolute concentrations
of N-acetylaspartate and choline were also significantly reduced in the
frontal white matter of patients with sleep apnoea.
Frontal lobe white matter lesions are known to be associated with
cognitive executive dysfunction. The findings of this study may offer an
explanation for the sometimes irreversible cognitive deficits associated
with sleep apnoea.
Συγγραφείς:
Alchanatis, M
Deligiorgis, N
Zias, N
Amfilochiou, A and
Gotsis, E
Karakatsani, A
Papadimitriou, A
Περιοδικό:
European Respiratory Journal
Εκδότης:
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Λέξεις-κλειδιά:
cerebral metabolism; proton magnetic resonance spectroscopy; sleep
apnoea syndrome
DOI:
10.1183/09031936.04.00127603
