Τίτλος:
Painful peripheral neuropathy associated with voriconazole use
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Voriconazole is a new antifungal agent that has been
recently introduced into clinical practice. We found no published
reports of painful peripheral neuropathy associated with its use.
Objective: To describe a unique case of painful peripheral neuropathy
associated with voriconazole use.
Setting: University hospital.
Patient: A 43-year-old patient who had undergone liver transplantation
received voriconazole for invasive deep sinus aspergillosis and
developed intolerable pain in all extremities.
Results: A laboratory workup and electromyographic and nerve conduction
studies were performed to exclude other causes of neuropathy in this
complicated patient. Results of electromyographic and nerve conduction
studies were suggestive of a demyelinating neuropathy. Symptoms and
signs of neuropathy disappeared shortly after voriconazole
discontinuation, suggesting a possible role in the development of
neuropathy. The patient continues to do well 10 months after this event.
Conclusions: To our knowledge, this is the first reported case of
voriconazole-associated peripheral neuropathy. Awareness of this
association and careful monitoring for neurological signs are necessary
for patients receiving voriconazole.
Συγγραφείς:
Tsiodras, S
Zafiropoulou, R
Kanta, E
Demponeras, C and
Karandreas, N
Manesis, EK
Περιοδικό:
Archives of Neurology and Psychiatry
Εκδότης:
AMER MEDICAL ASSOC
DOI:
10.1001/archneur.62.1.144
