Περίληψη:
The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C
polymorphism in the AT1R gene have been associated with left ventricular
remodelling and prognosis after acute myocardial infarction ( AMI). We
investigated whether these genetic variants associate with impaired left
ventricular ejection fraction ( LVEF) and increased risk for in-hospital
mortality after AMI. Consecutive AMI patients were recruited on
admission and were genotyped for the above-mentioned polymorphisms. The
frequency of the studied genotypes did not differ significantly between
deceased patients and those who survived. The LVEF did not differ among
patients with or without the DD genotype (45 +/- 10 vs. 45 +/- 10%,
p=0.892) or the CC genotype (45 +/- 10 vs. 46 +/- 10%, p=0.859). These
data question the role of the studied genotypes in the pathogenesis of
AMI and do not support the previously supported hypothesis that these
genotypes influence prognosis after AMI.
Συγγραφείς:
Andrikopoulos, GK
Tzeis, SM
Needham, EW
Richter, DJ and
Zairis, MN
Gialafos, EJ
Kardaras, FG
Foussas, SG and
Stefanadis, CI
Toutouzas, PK
Mattu, R
GEMIG Study Invest
