Τίτλος:
Basement membrane peptides: Functional considerations and biomedical
applications in autoimmunity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Basement membranes are specialized extracellular matrices that surround
certain cell types (muscle cells, adipose cells, etc) and are present
under the basal surface of cells exhibiting polarity (epithelial,
endothelial and mesothelial cells). They have a unique macromolecular
composition, consisting mainly of type IV collagen isoforms, laminin
isoforms, entactin/nidogen, and perlecan. These components self
associate and interact with each other to form networks. Other
macromolecules may be found in specialized basement membranes.
In this short review, the role of selected basement membrane proteins in
autoimmune diseases will be highlighted. As an example, Goodpasture’s
syndrome will be presented and the relatively long quest for
identification of the antigenic epitope on specific domains of the alpha
3(IV)NC1 will be summarized. Chagas disease will be discussed as an
example of laminin-mediated autoimmunity, with emphasis on the role of
sugar-based antigenic epitope(s) will be presented. Immune-mediated
tubulointerstitial nephritis will be introduced and the role of a
synthetic peptide in detecting proximal tubule damage in acute renal
failure will be discussed. Auto-immune diseases where other basement
membrane macromolecules are involved will be mentioned. Finally, the
importance of understanding the functions served by domains at close
proximity to the antigenic epitope(s) will be highlighted.
Συγγραφείς:
Charonis, A
Sideraki, V
Kaltezioti, V
Alberti, A and
Vlahakos, D
Wu, K
Tsilibary, E
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
basement membrane; type IV collagen; laminin; tubulointerstitial
nephritis antigen (TIN-ag); Goodpasture’s syndrome; Chagas disease
DOI:
10.2174/0929867054039071
