Τίτλος:
The effect of nicotinic acid and alcohol co-administration in Wistar
rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The effects of co-administration of nicotinic acid (NA) and alcohol
(Alc) on liver function in male Wistar rats were evaluated. The rats
were randomized into five groups: (i) Olive oil (Oil), (ii) Alc+Oil,
(iii) NA+Oil, (iv) NA+Alc+Oil, and (v) Controls (fed only normal rat
chow). Alanine aminotransferase (ALT), aspartate aminotransferase (AST),
alkaline phosphatase (AP), total cholesterol and triglycerides (TG) were
measured. Liver histopathology was also assessed. The Alc+Oil group had
higher TG levels compared with the NA+Alc+Oil group and all other
groups, as well. NA+Oil group had higher levels of AP compared with
Alc+Oil and Oil groups. The NA+Oil group had higher ALT levels compared
with the Oil group. The Oil group had lower ALT levels compared with the
control group. The Alc+Oil group had higher AST levels compared with the
NA+Alc+Oil group, as well as with all other groups. Liver histopathology
was within the normal range. A moderate amount of Alc daily together
with NA is safe in rats. The NA and Ale co-administration reduces the TG
and AST levels in rats, compared with the administration of Alc alone.
(c) 2005 Prous Science. All rights reserved.
Συγγραφείς:
Kolovou, GD
Mikhailidis, DP
Adamopoulou, EN
Salpea, KD and
Kafaltis, N
Bilianou, HG
Malakos, J
Pilatis, ND and
Mykoniatis, M
Cokkinos, DV
Περιοδικό:
Methods and Findings in Experimental and Clinical Pharmacology
Εκδότης:
PROUS SCIENCE, SAU-THOMSON REUTERS
Λέξεις-κλειδιά:
alcohol; hepatic enzymes; nicotinic acid; triglycerides
DOI:
10.1358/mf.2005.27.1.875432
