Τίτλος:
Erythropoietin levels in children and adolescents with inflammatory
bowel disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Iron deficiency anemia (IDA) and anemia of chronic disease (CDA) are
often encountered in patients with inflammatory bowel disease (IBD).
Inadequate intake or loss of iron is a clear cause of IDA, but
mechanisms of CDA induction are multifactorial and involve
erythropoiesis disturbance due to circulating inflammation mediators.
The authors investigated erythropoietin (Epo) levels in children and
adolescents with IBD and correlated them to disease activity, with the
aim of gaining an improved understanding of the role of Epo in CDA.
Thirty-three patients with IBD were examined (18 boys, 15 girls) ages 4
to 15 years (median 11 years). Two study groups related to the disease
activity were formed: group A, those with active disease (n = 21), and
group B, those in remission (n = 12). Epo levels were measured using a
two-site chemiluminescence immunoassay. Predictive Epo values in
response to the degree of anemia were calculated by the equation: logEpo
= (3.48 - 0.20) X Hb. According to the results, CDA anemia was present
only in patients with active disease. These patients also had a
significantly higher possibility of altered Epo levels than expected
compared with patients with inactive disease (16/21 vs. 4/12, P < 0.05).
It was also interesting that most of the patients with anomalous Epo
concentrations presented with an elevated Epo value compared with that
expected from the calculation (14/20). It seems that disturbed Epo
concentrations are correlated with disease activity in children and
adolescents with IBD. It is possible that failure of the bone marrow to
respond to increased Epo levels leads to further incremental response.
These in turn lead to the high Epo concentrations detected in most of
the authors’ patients. Impaired Epo production is another mechanism of
CDA development and is the one mainly expressed in patients with low Epo
values.
Συγγραφείς:
Tsitsika, A
Stamoulakatou, A
Kafritsa, Y
Paleologos, G and
Panayotou, I
Premetis, E
Roma, E
Papassotiriou, I
Περιοδικό:
Journal of Pediatric Hematology / Oncology
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
inflammatory bowel disease; anemia of chronic disease; iron deficiency
anemia; erythropoietin
DOI:
10.1097/01.mph.0000153441.34407.d9
