Τίτλος:
Evidence of reduced plasma HDL subfractions in patients with cutaneous
discoid lupus erythematosus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The aim of the present study was to evaluate the
dyslipidemic profile of patients with Cutaneous Discoid Lupus
Erythematosus (DLE) with particular emphasis oil the levels of High
Density Lipoprotein (HDL) Cholesterol and its subtractions, HDL2 and
HDL3.
Design and method: The Study involved characterization of the lipid
profile of 30 patients with diagnosed DLE (11 male and 19 female) and 34
age- and BMI-matched healthy individuals.
Results: Patients with DLE presented increased serum cholesterol,
triglycerides and LDL-Cholesterol levels (P < 0.001, respectively)
compared to the control group, while the levels of HDL-Cholesterol (P <
0.001), as well as its subtractions, HDL2 (P < 0.001) and HDL3 (P <
0.02) were markedly decreased. In addition, the ratio of CHOL/HDL was
increased in patients with DLE (P < 0.001), whereas a reduction was
observed in the ratio of HDL2/HDL3 (P < 0.001) in the same group.
Conclusions: Our findings suggest that patients with cutaneous discoid
lupus erythematosus have an increased risk of atherosclerosis due to the
marked dyslipidemia associated with the disease. The reduced levels of
HDL subtractions, HDL2 and HDL3, are believed to contribute to the
dyslipidemic profile and further provide an important target for
therapeutic intervention. (C) 2004 Published by The Canadian Society of
Clinical Chemists.
Συγγραφείς:
Lagogianni, I
Papapanagiotou, A
Piperi, C
Kalofoutis, C and
Troupis, G
Zachari, A
Kalofoutis, A
Περιοδικό:
Clinical Biochemistry
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
cutaneous discoid lupus erythematosus; HDL-C; HDL2; HDL3; LDL;
cholesterol; triglycerides
DOI:
10.1016/j.clinbiochem.2004.10.006
