Τίτλος:
Correlates of high-density mammographic parenchymal patterns by
menopausal status in a rural population in Northern Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Reproductive factors affect breast cancer risk, but less is known of
their associations with mammographic density and whether these differ by
menopausal status. We report on a cross-sectional study of 1946 pre- and
3047 post-menopausal women who joined a breast screening programme in
Northern Greece during 1993-1997. The odds of having a high-density
Wolfe pattern (P2/DY) was inversely associated with age (P for linear
trend < 0.001) in both pre- and post-menopausal women and, for
post-menopausal women, with years since menopause (P < 0.001). The odds
of a P2/DY pattern declined with higher parity (P < 0.001) and younger
age at first pregnancy (P = 0.05) in both pre- and post-menopausal
women. They also decreased with the duration of breast-feeding in
pre-menopausal women (P = 0.03 in pre- and P = 0.69 in post-menopausal
women; test for interaction with menopausal status: P = 0.07). Age at
menarche, age at menopause and the number of miscarriages/abortions were
not associated with mammographic density. Age at first pregnancy and
parity were strong correlates of mammographic density in pre- and
post-menopausal women while duration of breast-feeding appeared to be
particularly important in pre-menopausal women. (c) 2005 Elsevier Ltd.
All rights reserved.
Συγγραφείς:
Riza, E
Silva, ID
De Stavola, B
Perry, N and
Karadedou-Zafiriadou, E
Linos, D
Remoundos, DD
Linos, A
Περιοδικό:
EUROPEAN JOURNAL OF CANCER
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
breast density; mammographic parenchymal patterns; Wolfe classification;
menopausal status; reproductive variables; anthropometric variables;
breast cancer
DOI:
10.1016/j.ejca.2004.12.014
