Τίτλος:
The intrauterine origin of male breast cancer: a birth order study in
Denmark
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
First pregnancies are known to have higher oestrogen levels than later
ones and first-born women are at increased breast cancer risk compared
with later-born women. We hypothesized that a birth order effect might
be even more evident in male breast cancer patients, in whom oestrogens
in adult life are generally low. In a population-based study in Denmark
involving 77 male breast cancer patients and 288 population controls,
first-born men compared with later-born men had a relative risk of 1.71
for the disease (95% confidence interval (Cl) 1.00-2.92). This result
is in line with that seen in female breast cancer cases and indicates
that male breast cancer may have roots in the intrauterine life,
oestrogens being a likely mediator. (c) 2005 Lippincott Williams &
Wilkins.
Συγγραφείς:
Sorensen, HT
Olsen, ML
Mellemkjaer, L
Lagiou, P
Olsen,
JH
Olsen, J
Περιοδικό:
European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP)
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
birth order; case-control; in utero; male breast cancer
DOI:
10.1097/00008469-200504000-00016
