Περίληψη:
Epidemiological observations suggest that cancer arises from chronically
inflamed tissues. Inflammatory bowel disease (IBD) is a typical example
since patients with longstanding IBD are at increased risk for
development of colorectal cancer (CRC). Therefore, genetic factors
predisposing to or implicated in the chronic inflammatory process in IBD
may simultaneously predispose to CRC. Recently CARD15/NOD2 has been
associated with IBD, which further strengthens the notion that the
inflammatory response plays a crucial role in this disease. Several
mutations have been identified in the CARD15/NOD2 gene, which appear
with significantly higher frequency in patients with IBD. In this
report, we have examined the frequency of the 3 major mutations R702W,
G908R and 3020insC of the CARD2/NOD2 gene in a series of 104 consecutive
Greek patients with sporadic colorectal cancer and 100 healthy
individuals. The frequency of all the mutations was significantly
elevated compared to the control population (R702W, OR=5.00, p=0.023;
G908R, OR=2.78,p=0.025; 3020insC, OR=2.44,p=0.017). Patients with
advanced stage tumors were more frequently carriers of at least ‘
variant in the CARD15/NOD2 gene (p=0.009). Our results suggest that
CARD2/NOD2 may be a genetic factor that predispose to sporadic
colorectal cancer. (C) 2005 Wiley-Liss, Inc.
Συγγραφείς:
Papaconstantinou, L
Theodoropoulos, G
Gazouli, M and
Panoussopouios, D
Mantzaris, GJ
Felekouras, E
Bramis, J
