Τίτλος:
Effect of oral contraceptive treatment on bone mass acquisition in
skeletally immature young female rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The objective of the present study was to investigate the effect of oral
contraceptive (OC) treatment on bone mass accrual in skeletally immature
young female rats. Animals in the baseline group were killed at the
beginning of the experiment and were subjected to bone density
assessment by peripheral quantitative computerized tomogmphy (pQCT). The
control group was fed a base diet free of phytoestrogens, while animals
in the contraceptive group received the same base diet mixed with 2.67
mu g desogestrel/100 g body weight and 0.0533 mu g ethinyl estradiol/100
g body weight. The duration of the treatment period was 16 weeks.
Densitometric measurements by dual energy x-ray absorptiometry and serum
bone markers assessment were carried out at baseline, at 8 weeks and at
16 weeks, while pQCT densitometry took place after sacrifice. All bone
mineral density and bone mineral content indices measured by dual energy
x-ray absorptiometry increased significantly throughout the study period
in both the OC and control group. Concerning pQCT measurements, animals
in both the OC and the control group had significantly higher cortical
density compared with baseline (midtibia: p=.0003 and .0003,
respectively). Total area and periosteal circumference were
significantly higher in OC group, both in proximal (p=.003 and .003,
respectively) and midtibia (P=.048 and .042, respectively) compared with
baseline. Osteoprotegerin serum levels increased in both groups, and at
the end of the experiment, circulating osteoprotegerin was significantly
higher in the OC group compared with controls (p=.032). At the end of
the experiment, carboxyl-terminal telopeptides of collagen type I levels
were significantly lower in the OC-treated animals compared with
controls (p=.046). Our results suggest that OC administration to
skeletally immature female rats allows normal bone accrual and may even
improve bone geometry. This effect may be mediated through enhanced
inhibition of bone resorption. (c) 2005 Elsevier Inc. All rights
reserved.
Συγγραφείς:
Eleftheriades, MI
Lambrinoudaki, IV
Christodoulakos, GE and
Gregoriou, OV
Economou, EV
Kouskouni, EE
Antoniou, AG and
Perrea, DN
Dontas, IA
Raptou, PD
Lyritis, GP
Creatsas,
GC
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
bone mass accrual; oral contraceptive; osteoprotegerin; Wistar rat;
C-telopeptides of collagen type I
DOI:
10.1016/j.contraception.2004.10.009
