Τίτλος:
Fatal Blastoschizomyces capitatus sepsis in a neutropenic patient with
acute myeloid leukemia: first documented case from Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Blastoschizomyces capitatus (formerly known as Geotrichum capitatum and
Trichosporon capitatum) is a rare, yet an emerging, cause of invasive
infections in immunosuppressed patients. Profound and prolonged
neutropenia is the crucial predisposing factor for this yeast infection.
Blastoschizomyces capitatus was isolated from peripheral blood cultures
of a profoundly neutropenic patient with acute myeloid leukemia (M2
FAB). Despite administration of antifungal chemotherapy with liposomal
amphotericin B at 4.5 mg kg(-1) daily, the patient succumbed 4 days
after initiation of treatment. Infections attributed to B. capitatus
have generally a poor prognosis, although the yeast shows in vitro
susceptibility to antifungal agents. Low flucytosine, caspofungin
acetate, voriconazole and amphotericin B minimum inhibitory
concentration values were also recorded with our isolate. The clinical
relevance of the in vitro susceptibility testing against the isolate and
the current antifungal chemotherapy regimens against B. capitatus
systemic infections are discussed.
Συγγραφείς:
Christakis, G
Perlorentzou, S
Aslanidou, M
Megalakaki, A and
Velegraki, A
Λέξεις-κλειδιά:
Blastoschizomyces capitatus; neutropenia; sepsis
DOI:
10.1111/j.1439-0507.2005.01098.x
