Τίτλος:
C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional
study in healthy women within the European Prospective Investigation
into Cancer and Nutrition (EPIC)
Περίληψη:
Objectives: The risk of some cancers is positively associated with body
weight, which may influence circulating levels of sex-steroid hormones,
insulin and IGF-I. Interrelationships between these hormones and the
associations with adiposity were evaluated in healthy women
participating in the European Prospective Investigation into Cancer and
Nutrition (EPIC).
Methods: A cross-sectional analysis was performed on anthropometric and
hormonal data from 743 pre- and 1217 postmenopausal women. Body mass
index (BMI) and waist circumference were used as indicators of
adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth
Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone
binding globulin (SHBG) were measured by immunoassays; free sex steroid
concentrations were calculated.
Results: BMI and waist circumference were positively correlated with
estrogens in postmenopausal women and with C-peptide, free testosterone
and inversely with SHBG in all women. C-peptide and IGF-I were inversely
correlated with SHBG, and positively with free sex steroids in
postmenopausal women. IGF-I was positively associated with
postmenopausal estrogens and androgen concentrations in all women.
Conclusions: Sex-steroid concentrations appear to be regulated along
several axes. Adiposity correlated directly with estrogens in
postmenopausal women and with insulin, resulting in lower SHBG and
increased levels of free sex steroids. Independent of adiposity and
insulin, IGF-I was associated with decreased SHBG levels, and increased
concentrations of androgens and postmenopausal estrogens.
Συγγραφείς:
Bezemer, ID
Rinaldi, S
Dossus, L
van Gils, CH
Peeters,
PHM
Noord, PAH
Bueno-de-Mesquita, HB
Johnsen, SP and
Overvad, K
Olsen, A
Tjonneland, A
Boeing, H
Lahmann, PH
and Linseisen, J
Nagel, G
Allen, N
Roddam, A
Bingham, S
and Khaw, KT
Kesse, E
Tehard, B
Clavel-Chapelon, F and
Agudo, A
Ardanaz, E
Quiros, JR
Amiano, P and
Martinez-Garcia, C
Tormo, MJ
Pala, V
Panico, S
Vineis, P
and Palli, D
Tumino, R
Trichopoulou, A
Baibas, N
Zilis,
D
Hemon, B
Norat, T
Riboli, E
Kaaks, R
