Περίληψη:
The effect of multivariate adjustment including folate on the strong
protective effect of fiber in foods on colorectal cancer risk in the
European Prospective Investigation into Cancer and Nutrition was
investigated in 1,721 cases identified in the latest follow-up. The
inclusion of an additional 656 cases confirmed our previously published
results, with a strong and significant reduction in colorectal cancer
risk of similar to 9% for each uncalibrated quintile increase in fiber
(P-linear trend < 0.001) compared with an 8% reduction in our previous
report, which had not been adjusted for folate. Inclusion of the other
covariates (physical activity, alcohol, smoking, and red and processed
meat) confirmed this significant inverse association for colon cancer
and strengthened the association with left-sided colon cancer (P <
0.001). After maximum adjustment, the association between fiber and
rectal cancer was not significant, as in our previous analysis. The
association with fiber from different food sources was analyzed, but
again, there were no significance trends after maximum adjustment.
Συγγραφείς:
Bingham, SA
Norat, T
Moskal, A
Ferrari, P
Slimani, N and
Clavel-Chapelon, F
Kesse, E
Nieters, A
Boeing, H and
Tjonneland, A
Overvad, K
Martinez, C
Dorronsoro, M and
Gonzalez, CA
Ardanaz, E
Navarro, C
Quiros, JR
Key, TJ
and Day, NE
Trichopoulou, A
Naska, A
Krogh, V
Tumino, R
and Palli, D
Panico, S
Vineis, P
Bueno-de-Mesquita, HB and
Ocke, MC
Peeters, PHM
Berglund, G
Hallmans, G
Lund, E
and Skeie, G
Kaaks, R
Riboli, E
