Τίτλος:
Rapid cycling bipolar disorder: biology and pathogenesis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The rapid cycling (RC) pattern of a mood disorder is characterized by at
least four affective episodes (manic, hypomanic or major depressive)
during the last year; different episodes must be demarcated by a switch
to an episode of opposite polarity or by a period of remission of at
least 2 months. RC is very rare in unipolar patients; its prevalence,
however, in bipolar patients is 10-30 % with the majority being women
(70-90 %). Patients with RC usually suffer from bipolar II disorder
with onset with a depressive episode. Genetic studies have not
convincingly shown that the condition is genetically determined. Major
abnormalities of thyroid function have not been shown to be related to
RC, but recent studies propose that latent subclinical hypothyroidism
might play a role in the acceleration of cycles. Perturbations of the
circadian biological and social rhythms might influence the expression
of RC. No major effect of the menstrual cycle has been found. Despite
the absence of firm empirical data, the possible contribution of the
kindling phenomenon on the acceleration of cycles cannot be excluded.
Finally, there is evidence that RC can be induced by the use of
antidepressant drugs, especially for women.
Συγγραφείς:
Papadimitriou, GN
Calabrese, JR
Dikeos, DG
Christodoulou, GN
Περιοδικό:
The International Journal of Neuropsychopharmacology
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
aetiology; genetics; psychotropic drugs; rapid cycling mood disorder
DOI:
10.1017/S1461145705005092
