Περίληψη:
Background: Medical Research Council (MRC) chronic dyspnea scale, used
for the estimation of disability due to dyspnea, may serve as a simple
index of disease severity and extent in patients with idiopathic
pulmonary fibrosis (IPF). However, its relationship with other commonly
used measures has not been evaluated.
Methods: The association of MRC chronic dyspnea scale with lung function
indices and high-resolution computerized tomography (HRCT) scores such
as the total interstitial disease score (TIDs) and the fibrosis score
(Fs) was examined in 26 untreated patients with IPF sequentially
recruited over a period of 3 years. The aim of this observational study
was to explore the relationship between dyspnea, impairment of lung
function and CT estimation of disease severity in patients with IPF
Results: The MRC dyspnea score was significantly associated with FVC,
FEV1, TLC, DLCO, PaO2, and PaCO2 and with both HRCT scores. In multiple
regression analysis only the FVC (OR 0.85, 95 % Cl = 0.75-0.95, P =
0.004) and PaCO2 (OR = 0.69, 95 % Cl = 0.50-0.95, P = 0.02) correlated
with dyspnea. Furthermore, both TIDs and Fs were negatively associated
with FVC, FEV1, TLC and PaO2. In multiple regression analysis only the
FVC correlated with both TIDs (r(2) = 0.57, P = 0.0001) and Fs (r(2) =
0.46, P = 0.0005).
Conclusions: These observations suggest that the MRC dyspnea scale could
offer useful information about the estimation of severity in patients
with IPF. Furthermore among functional indices the FVC seems to be the
best estimator of disease severity and extent. (c) 2004 Elsevier Ltd.
All rights reserved.
Συγγραφείς:
Papiris, SA
Daniil, ZD
Malagari, K
Kapotsis, GE and
Sotiropoulou, C
Milic-Emili, J
Roussos, C
