Περίληψη:
Coffee is one of the most widely used pharmacologically active
beverages. The present study was designed to evaluate the acute effect
of coffee ingestion on endothelial function in healthy individuals, and
the potential role of caffeine. We studied 17 healthy young adults (28.9
+/- 3.0 years old; nine men), who were regular non-heavy coffee
drinkers. The endothelial performance was estimated by
endothelium-dependent FMD (flow-mediated dilatation) of the brachial
artery before and 30, 60, 90 and 120 min after ingestion of a cup of
caffeinated coffee (80 mg of caffeine) or the corresponding
decaffeinated beverage (< 2 mg of caffeine) in two separate sessions,
following a randomized single-blind cross-over design. There was no
difference in baseline FMD values between the two sessions [7.78
compared with 7.07% after caffeinated and decaffeinated coffee
respectively; P = NS (not significant)]. Caffeinated coffee led to a
decline of FMD (7.78, 2.86, 2.12, 4.44 and 4.57 % at baseline, 30, 60,
90 and 120 min respectively; P < 0.001). This adverse effect was focused
at 30 (P = 0.004) and 60 min (P < 0.001). No significant effect on FMD
was found with the decaffeinated coffee session (7.07, 6.24, 5.21, 7.41
and 5.20 %; P = NS). The composite effect of the type of coffee
consumed over time on FMD was significantly different (P = 0.021). In
conclusion, coffee exerts an acute unfavourable effect on the
endothelial function in healthy adults, lasting for at least I h after
intake. This effect might be attributed to caffeine, given that
decaffeinated coffee was not associated with any change in the
endothelial performance.
Συγγραφείς:
Papamichael, CM
Aznaouridis, KA
Karatzis, EN
Karatzi, KN and
Stamatelopoulos, KS
Vamvakou, G
Lekakis, JP
Mavrikakis, ME
