Περίληψη:
Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest fertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P = 0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P = 0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest fertile were 1.44 (95% CI 0.88-2.36; P = 0.05) and 2.05 (95% CI 1.23-3.42; P = 0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest fertile was 0.57, 95% CI 0.34-0.95; P = 0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women. © 2008 Society for Endocrinology.
Συγγραφείς:
Allen, N.E.
Key, T.J.
Dossus, L.
Rinaldi, S.
Cust, A.
Lukanova, A.
Peeters, P.H.
Onland-Moret, N.C.
Lahmann, P.H.
Berrino, F.
Panico, S.
Larrahaga, N.
Pera, G.
Tormo, M.-J.
Sánchez, M.-J.
Quirós, J.R.
Ardanaz, E.
Tjønneland, A.
Olsen, A.
Chang-Claude, J.
Linseisen, J.
Schulz, M.
Boeing, H.
Lundin, E.
Palli, D.
Overvad, K.
Clavel-Chapelon, F.
Boutron-Ruault, M.-C.
Bingham, S.
Khaw, K.-T.
Bueno-De-Mesquita, H.B.
Trichopoulou, A.
Trichopoulos, D.
Naska, A.
Tumino, R.
Riboli, B.
Kaaks, R.
Λέξεις-κλειδιά:
androstenedione; estradiol; estrone; prasterone sulfate; sex hormone; sex hormone binding globulin; testosterone, adult; age; aged; androgen blood level; androstenedione blood level; article; blood sampling; cancer risk; case control study; controlled study; disease association; endometrium cancer; estradiol blood level; estrone blood level; European Prospective Investigation into Cancer and nutrition; female; health survey; hormone blood level; human; major clinical study; menopause; menstrual cycle; premenopause; protein blood level; regression analysis; testosterone blood level, Adult; Aged; Androstenedione; Body Mass Index; Dehydroepiandrosterone Sulfate; Endometrial Neoplasms; Estradiol; Estrone; Europe; Female; Gonadal Steroid Hormones; Humans; Incidence; Middle Aged; Odds Ratio; Postmenopause; Premenopause; Prospective Studies; Risk Factors; Sex Hormone-Binding Globulin; Testosterone
