Τίτλος:
Brain metastases from epithelial ovarian cancer: A review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Brain metastases from epithelial ovarian cancer (EOC) are rare. This report is based on a review of the literature. Methods and Results. This review summarizes the incidence, clinical features, pathophysiology, and diagnostic evaluation of EOC. The section on current treatment includes a thorough evaluation of the literature, highlights controversies over treatment options, and provides insight into novel approaches. Current treatment options include surgical resection, whole-brain radiation therapy (WBRT), stereotactic radiosurgery, and chemotherapy. Corticosteroids and anticonvulsant medications are commonly used for the palliation of mass effects and seizures, respectively. In the reviewed series, a better outcome was seen following surgical resection and WBRT with or without chemotherapy for solitary and resectable brain metastases. Conclusion. The prognosis for patients with brain metastases from EOC is poor. A better outcome might be obtained using multimodality therapy. Because of the small number of patients included in the reported studies, multicenter clinical trials are needed for further investigation in order to critically evaluate the clear benefit of these treatment options in selected patients. ©AlphaMed Press.
Συγγραφείς:
Pectasides, D.
Pectasides, M.
Economopoulos, T.
Περιοδικό:
The oncologist
Λέξεις-κλειδιά:
anticonvulsive agent; carbamazepine; cisplatin; corticosteroid; dexamethasone; gemcitabine; mannitol; paclitaxel; phenobarbital; phenytoin; valproic acid, brain edema; brain metastasis; cancer chemotherapy; cancer diagnosis; cancer grading; cancer localization; cancer palliative therapy; cancer radiotherapy; cancer relapse; cancer staging; cancer surgery; cerebrospinal fluid analysis; clinical feature; computer assisted tomography; craniotomy; drug effect; drug mechanism; gamma knife radiosurgery; headache; histopathology; human; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; ovary cancer; pathophysiology; priority journal; radiosurgery; review; seizure; stereotaxic surgery, Adrenal Cortex Hormones; Brain Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Incidence; Neoplasm Staging; Ovarian Neoplasms; Radiosurgery; Radiotherapy, Adjuvant
DOI:
10.1634/theoncologist.11-3-252
