Τίτλος:
Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Interleukin-1 (IL-1) is a cytokine involved in the maturation and proliferation of B cells and plays a significant role in the development of lytic bone lesions, a major clinical feature of multiple myeloma (MM) patients. Genes that regulate products involved in the immune system are highly polymorphic and contribute to inter-individual differences that can influence the genetic predisposition and progression of particular diseases and cancers. In this study, we investigated the correlation between the single nucleotide polymorphisms IL1A -889, IL1B -511, IL1B +3954, IL1RN Mspa1 +11100 and susceptibility to MM in 74 patients and 160 controls. We found that individuals possessing IL1A -889 CT polymorphism had a higher risk in developing MM. Moreover, genotypes IL1B -511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL 1B +3954 CC with IL1B -511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them.
Συγγραφείς:
Abazis-Stamboulieh, D.
Oikonomou, P.
Papadoulis, N.
Panayiotidis, P.
Vrakidou, E.
Tsezou, A.
Περιοδικό:
Clinical Lymphoma Myeloma and Leukemia
Λέξεις-κλειδιά:
interleukin 1 receptor blocking agent; interleukin 1alpha; interleukin 1beta, adult; aged; article; cancer susceptibility; cell maturation; cell proliferation; controlled study; disease course; DNA polymorphism; female; gene control; genetic predisposition; human; immune system; major clinical study; male; multiple myeloma; priority journal; single nucleotide polymorphism, Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Gene Frequency; Genotype; Greece; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Linkage (Genetics); Male; Middle Aged; Multiple Myeloma; Polymorphism, Single Nucleotide
DOI:
10.1080/10428190701615892
