Τίτλος:
Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim of this study was to assess non-invasively endothelial function of young women with polycystic ovary syndrome (PCOS) in comparison with healthy age-matched women and a group of young women with idiopathic hirsutism (IH). The possible role of metabolic and hormonal parameters on endothelial function was also examined. Design: Descriptive clinical trial. Methods: Fifty-six women, 27 with PCOS, 16 with IH and 13 healthy age-matched women were studied. Endothelial function of resistance arteries was assessed by venous occlusion plethysmography. Metabolic and hormonal parameters were estimated in this study population. Results: T he duration of reactive hyperemia (durRH) was shorter in PCOS group when compared with normal controls (63.75±13.33 s vs 113.18±20.92 s, P=0.036). A similar finding was observed when PCOS were compared with IH group (63.75±13.33 svs 105±17.20 s, P=0.05).The durRH did not differ between IH and control group (105±17.20 svs 113.18±20.92 s, ns). A significant positive linear correlation was found between the durRH and dehydroepiandrosterone-sulfate (DHEA-S) levels (r= +0.48, P=0.04) in the PCOS group. The basal insulin resistance index (HOMA) differed significantly between PCOS, IH and control groups. There was no significant correlation between durRH and HOMA index or testosterone levels in the PCOS group. Conclusions: Endot helial dysfunction may be an early sign of cardiovascular system abnormalities in young PCOS women. It is possible that increased DHEA-S levels may offer a cardioprotective advantage that attenuates the effects of cardiovascular risk factors that accompany PCOS. © 2006 Society of the European Journal of Endocrinology.
Συγγραφείς:
Dagre, A.
Lekakis, J.
Mihas, C.
Protogerou, A.
Thalassinou, L.
Tryfonopoulos, D.
Douridas, G.
Papamichael, C.
Alevizaki, M.
Περιοδικό:
European Journal of Endocrinology
Λέξεις-κλειδιά:
insulin; prasterone sulfate; testosterone, adult; artery resistance; article; attenuation; cardiovascular disease; cardiovascular risk; clinical article; clinical trial; controlled clinical trial; controlled study; correlation analysis; descriptive research; endothelial dysfunction; female; functional assessment; heart protection; hirsutism; homeostasis; human; hyperemia; insulin resistance; metabolic parameters; ovary polycystic disease; population research; priority journal; risk factor; statistical significance; vascular endothelium; vein occlusion plethysmography, Adult; Dehydroepiandrosterone Sulfate; Endothelium, Vascular; Female; Forearm; Hirsutism; Humans; Hyperemia; Plethysmography; Polycystic Ovary Syndrome; Regional Blood Flow
