Τίτλος:
Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Despite our growing insight into carcinogenesis, treatment of tumors, especially nonsmall cell lung cancer (NSCLC), remains limited and it is urgent to develop strategies that target tumor cells and their genetic features. Drug discovery efforts have historically focused on the search for compounds that modulate the protein products of genes. Current drug therapy targets only a few hundred endogenous targets, mainly proteins, such as receptors and enzymes. But now, the interest in specifically targeting RNA is increasing, both for target validation and/or therapeutic purposes. In this regard, our work was concerned with the induction of new molecular targets correlated to a cytostatic effect on NSCLC cell line, after treatment with a new triazin named A190. The in vitro study of cell cycle and apoptosis induction demonstrated the antiproliferative potential of this new compounds, and the use of quantitative RT-PCR analysis permit to display an original mechanism of action involving 2 genes: HEF1 and B2. The antitumor effect was also confirmed by the good results in vivo on nude mice xenografts. © 2008 Wiley-Liss, Inc.
Συγγραφείς:
Moreau, D.
Jacquot, C.
Tsita, P.
Chinou, I.
Tomasoni, C.
Juge, M.
Antoniadou-Vyza, E.
Martignat, L.
Pineau, A.
Roussakis, C.
Περιοδικό:
International Journal of Cancer
Λέξεις-κλειδιά:
4,6 diamino 1,2 dihydro 1 (4'' chlorophenyl) 2 (1 tricyclo[3.3.1.1 3,4 ] decyl 1,3,5 triazine; a 190; antineoplastic agent; triazine derivative; unclassified drug, animal experiment; animal model; antineoplastic activity; apoptosis; article; b2 gene; cancer cell; cancer cell culture; cell cycle; controlled study; cytostasis; drug mechanism; drug targeting; female; gene; hef1 gene; human; human cell; in vitro study; lung non small cell cancer; mitosis inhibition; molecular therapy; mouse; nonhuman; nucleotide sequence; nude mouse; priority journal; protein targeting; quantitative analysis; reverse transcription polymerase chain reaction; tumor xenograft, Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Female; Lung Neoplasms; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Structure; Phosphoproteins; Triazines; Xenograft Model Antitumor Assays
