Τίτλος:
Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8. © 2005 Elsevier Inc. All rights reserved.
Συγγραφείς:
Tsirigotis, P.
Papageorgiou, S.
Abatzis, D.
Athanatou, S.
Girkas, C.
Pappa, V.
Pangalos, C.
Papageorgiou, E.
Dervenoulas, J.
Raptis, S.
Περιοδικό:
CANCER GENETICS AND CYTOGENETICS
Λέξεις-κλειδιά:
cytarabine; etoposide; idarubicin, acute granulocytic leukemia; adult; article; bone marrow biopsy; cancer chemotherapy; cancer cytodiagnosis; cancer prevention; case report; chromosome 8; female; flow cytometry; human; priority journal; prognosis; recurrent cancer; relapse; salvage therapy; tetrasomy, Adult; Aneuploidy; Chromosome Aberrations; Chromosomes, Human, Pair 8; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myelocytic, Acute; Prognosis
DOI:
10.1016/j.cancergencyto.2004.12.016
