Τίτλος:
Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction. Hypertension results from the interaction of genetic and environmental factors. Since the renin-angiotensin and the natriuretic peptide systems contribute to blood pressure regulation, variations in the relative genes are candidates for the development of hypertension. Materials and methods. In 194 hypertensives and 304 controls of Hellenic origin, the possible association between the (CA)n repeat polymorphism of angiotensinogen (AGT), the 250 bp insertion/deletion (I/ D) of angiotensin-converting enzyme (ACE), the tetranucleotide repeat polymorphism (TCTG)n of renin, and the (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) and hypertension was assessed. Results. No association between AGT and NPRA polymorphisms and hypertension was observed. The presence of ID or DD genotype of ACE was associated with an increased risk for hypertension compared with the II genotype (OR: 1.782 [95% CI: 1.032-3.077]), whereas the LL genotype of the renin gene was associated with a decreased risk compared with the SS genotype (OR: 0.174 [95% CI: 0.044-0.689]). However, after adjustment for confounding factors only the latter association remained. Conclusions. In the present study conducted in a homogeneous Hellenic population, no associations between AGT, ACE, and NPRA gene polymorphisms and hypertension were found. The presence of a significant negative association between the LL polymorphism of the renin gene and hypertension requires further confirmation. © 2008 SAGE Publications.
Συγγραφείς:
Tsezou, A.
Karayannis, G.
Giannatou, E.
Papanikolaou, V.
Triposkiadis, F.
Περιοδικό:
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Λέξεις-κλειδιά:
angiotensinogen; dipeptidyl carboxypeptidase; low density lipoprotein; natriuretic peptide receptor A; renin; angiotensinogen; atrial natriuretic factor receptor; dipeptidyl carboxypeptidase; natriuretic peptide receptor A, adult; aged; article; controlled study; dinucleotide repeat; DNA polymorphism; female; gene deletion; gene frequency; gene insertion; genetic association; genotype; Greece; human; hypertension; major clinical study; male; nucleotide repeat; population research; risk assessment; tetranucleotide repeat; Caucasian; demography; genetic polymorphism; genetic predisposition; genetics; multivariate analysis; renin angiotensin aldosterone system; risk, Aged; Angiotensinogen; Demography; European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Greece; Humans; Hypertension; Male; Multivariate Analysis; Odds Ratio; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, Atrial Natriuretic Factor; Renin-Angiotensin System
DOI:
10.1177/1470320308096412
