Τίτλος:
Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight. © 2006 Blackwell Publishing Ltd.
Συγγραφείς:
Pantos, C.
Mourouzis, I.
Paizis, I.
Malliopoulou, V.
Xinaris, Ch.
Moraitis, P.
Cokkinos, A.D.
Cokkinos, D.V.
Περιοδικό:
Diabetes, Obesity and Metabolism
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
dronedarone; levothyroxine; thyroid hormone; thyroid hormone receptor alpha; thyroid hormone receptor alpha1; amiodarone; dronedarone; drug derivative; thyroid hormone receptor alpha; thyroxine, animal experiment; animal model; article; body weight; controlled study; drug potentiation; food intake; heart rate variability; hormonal regulation; hormone binding; nonhuman; obesity; rat; receptor blocking; weight reduction; animal; drug antagonism; drug effect; eating; letter; Wistar rat, Amiodarone; Animals; Drug Synergism; Eating; Rats; Rats, Wistar; Thyroid Hormone Receptors alpha; Thyroxine; Weight Loss
DOI:
10.1111/j.1463-1326.2006.00587.x
