Περίληψη:
In type 2 diabetes, the threonine (Thr) for alanine (Ala) codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with elevated fasting and postprandial triglycerides and dyslipidemia when compared with the wild type (Ala-54/Ala-54). To assess whether this is the case in patients with type 1 diabetes, who usually do not manifest the metabolic syndrome, we screened 181 patients with similar glycemic control as the type 2 patients. Thirty percent were heterozygous, and 9% were homozygous for the polymorphism. Mean (± SEM) fasting plasma triglyceride levels in patients with the wild type (n = 84), those heterozygous for Ala-54/Thr-54 (n = 44), and those homozygous for the Thr-54 (n = 13) were 1.0 ± 0.07, 1.1 ± 0.17, and 1.2 ± 0.23 mmol/liter, respectively. In addition, there were no differences in total, low-density lipoprotein, high-density lipoprotein, and non-high density lipoprotein cholesterol among the three groups. After a fat load, the postprandial area under the curve of triglyceride in plasma, chylomicrons, and very low-density lipoprotein were similar between the wild type (n = 18) and the Thr-54 homozygotes (n = 12). In conclusion, in contrast to type 2, type 1 diabetes does not interact with the codon 54 polymorphism of the fatty acid binding protein 2 gene to cause hypertriglyceridemiea/dyslipidemia. Insulin resistance could account possibly for this difference.
Συγγραφείς:
Georgopoulos, A.
Aras, O.
Noutsou, M.
Tsai, M.Y.
Λέξεις-κλειδιά:
alanine; chylomicron; fatty acid binding protein; fatty acid binding protein 2; high density lipoprotein cholesterol; low density lipoprotein cholesterol; threonine; triacylglycerol; unclassified drug; very low density lipoprotein, area under the curve; article; codon; controlled study; DNA polymorphism; dyslipidemia; heterozygosity; homozygosity; human; hypertriglyceridemia; insulin dependent diabetes mellitus; insulin resistance; molecular interaction; non insulin dependent diabetes mellitus; postprandial state; priority journal; triacylglycerol blood level
