Περίληψη:
We report the identification of a new simian immunodeficiency virus
(SIV), designated SIVden, in a naturally infected Dent’s Mona monkey
(Cercopithecus mona denti), which was kept as pet in Kinshasa, capital
of the Democratic Republic of Congo. SIVden is genetically distinct from
the previously characterized primate lentiviruses. Analysis of the
full-length genomic sequence revealed the presence of a vpu open reading
frame. This gene is also found in the virus lineage of human
immunodeficiency virus type 1 (HIV-1) and chimpanzee immunodeficiency
virus (SIVcpz) and was recently described in viruses isolated from
Cercopithecus nictitans, Cercopithecus mona, and Cercopithecus cephus.
The SIVden vpu coding region is shorter than the RIV-I/SlVcpz and the
SIVgsn, SIVmon, and SIVmus counterparts. Unlike Pan troglodytes
schweinfurthii viruses (SIVcpzPts) and Cercopithecus monkey viruses
(SIVgsn, SIVmon, and SIVmus), the SIVden Vpu contains the characteristic
DSGXES motif which was shown to be involved in Vpu-mediated CD4 and I
kappa B alpha proteolysis in HIV-1 infected cells. Although it harbors a
vpu gene, SIVden is phylogenetically closer to SIVdeb isolated from De
Brazza’s monkeys (Cercopithecus neglectus), which lacks a vpu gene, than
to Cercopithecus monkey viruses, which harbor a vpu sequence.
Συγγραφείς:
Dazza, MC
Ekwalanga, M
Nende, M
Bin Shamamba, K
Bitshi,
P
Paraskevis, D
Saragosti, S
