Τίτλος:
Microscopic polyangiitis complicated by the development of prostate
cancer and utamide-induced hepatitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We report a case of a 65-year-old man with microscopic polyangiitis who
developed prostate cancer and gastric adenocarcinoma after prolonged
oral use of cyclophosphamide. Acute hepatitis with jaundice and marked
increase in aminotranferases occurred after 6 months of flutamide
treatment for metastatic prostate carcinoma. It is suggested that
patients with vasculitis or other autoimmune disorders should avoid
prolonged use of cyclophosphamide and other cytotoxic drugs in order to
minimize long-term adverse effects, of which the risk of cancer is by
far the most important. In patients on flutamide treatment, careful
monitoring of flutamide administration with repeated liver function
tests should be undertaken, and the drug must be immediately
discontinued in patients with abnormal results to avoid progression of
liver injury.
Συγγραφείς:
Papaioannides, D.
Korantzopoulos, P.
Bouropoulos, C.
Latsi,
P.
Fotinou, M.
Orphanidou, D.
Περιοδικό:
International Urology and Nephrology
Λέξεις-κλειδιά:
flutamide; hepatitis; microscopic polyangiitis; prostate cancer;
vasculitis
DOI:
10.1007/s11255-005-2093-0
