Τίτλος:
Mycobacterium avium subsp paratuberculosis, genetic susceptibility to
Crohn's disease, and Sardinians: the way ahead
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study was performed to determine what proportion of people
in Sardinia with or without Crohn’s disease were infected with
Mycobacterium avium subspecies paratuberculosis and had a preponderance
of allelic variants of Nod2, an intracellular protein involved in
Crohn’s disease susceptibility. Genetic analysis of the alleles of the
NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to
susceptibility or genetic predisposition to Crohn’s disease in humans,
was carried out on specimens from 37 Crohn’s disease patients and 34
patients without Crohn’s disease. Our results show that more than 70
percent of people in Sardinia with Crohn’s disease carry at least one of
the susceptibility-associated NOD2/CARD15 alleles and were infected with
Mycobacterium avium subspecies paratuberculosis.
Συγγραφείς:
Sechi, LA
Gazouli, M
Ikonomopoulos, J
Lukas, JC
Scanu,
AM
Ahmed, N
Fadda, G
Zanetti, S
Περιοδικό:
Journal of Clinical Microbiology
Εκδότης:
AMER SOC MICROBIOLOGY
DOI:
10.1128/JCM.43.10.5275-5277.2005
