Τίτλος:
Acute systemic inflammation increases arterial stiffness and decreases
wave reflections in healthy individuals
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background-Aortic stiffness is a marker of cardiovascular disease and an
independent predictor of cardiovascular risk. Although an association
between inflammatory markers and increased arterial stiffness has been
suggested, the causative relationship between inflammation and arterial
stiffness has not been investigated.
Methods and Results-One hundred healthy individuals were studied
according to a randomized, double-blind, sham procedure-controlled
design. Each substudy consisted of 2 treatment arms, 1 with Salmonella
typhi vaccination and 1 with sham vaccination. Vaccination produced a
significant ( P < 0.01) increase in pulse wave velocity ( at 8 hours by
0.43 m/s), denoting an increase in aortic stiffness. Wave reflections
were reduced significantly ( P < 0.01) by vaccination ( decrease in
augmentation index of 5.0% at 8 hours and 2.5% at 32 hours) as a
result of peripheral vasodilatation. These effects were associated with
significant increases in inflammatory markers such as high-sensitivity
C-reactive protein ( P < 0.001), high-sensitivity interleukin- 6 ( P <
0.001), and matrix metalloproteinase-9 ( P < 0.01). With aspirin
pretreatment ( 1200 mg PO), neither pulse wave velocity nor augmentation
index changed significantly after vaccination ( increase of 0.11 m/s and
0.4%, respectively; P = NS for both).
Conclusions-This is the first study to show through a cause-and-effect
relationship that acute systemic inflammation leads to deterioration of
large-artery stiffness and to a decrease in wave reflections. These
findings have important implications, given the importance of aortic
stiffness for cardiovascular function and risk and the potential of
therapeutic interventions with antiinflammatory properties.
Συγγραφείς:
Vlachopoulos, C
Dima, I
Aznaouridis, K
Vasiliadou, C and
Ioakeimidis, N
Aggeli, C
Toutouza, M
Stefanadis, C
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
arterial stiffness; atherosclerosis; endothelium; inflammation; wave
reflections
DOI:
10.1161/CIRCULATIONAHA.105.535435
