Τίτλος:
Ketamine-induced changes in metabolic and endocrine parameters of normal
and 2-kidney 1-clip rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and objective: The aim of this study was to investigate the
effect of ketamine on the endocrine and lipid metabolic status of the
renal-banded animals. Methods: Forty male rats were randomly divided
into four groups. Group A served as control, Group B animals received
ketamine intraperitoneally at a dose of 100 mg kg(-1), Group C was
submitted to 2-kidney 1-clip experimental hypertension and Group D
received ketamine as above, as well as being submitted to renal artery
clipping. Atrial natriuretic peptide, angiotensin II and free fatty acid
concentrations were measured in serum. In addition, adipose tissue
lipoprotein lipase activity and angiotensin II content were determined,
while the left ventricular weight relative to body weight was used as a
cardiac hypertrophy index. Results: In renal-banded rats (Groups C and
D) serum atrial natriuretic peptide, free fatty acid and angiotensin II
concentrations as well as ventricular weight were increased, while
adipose tissue lipoprotein lipase activity was lower than in control
animals (Groups A and B). Ketamine administration did not influence
angiotensin II concentrations either in normal (Group B) or banded rats
(Group D). Ketamine increased serum atrial natriuretic peptide and free
fatty acid concentrations only in normal animals (Group B). It had no
influence on adipose tissue lipoprotein lipase activity either in normal
(Group B) or banded animals (Group D). Adipose angiotensin II content
did not differ between the four groups. Conclusion: Ketamine increased
the atrial natriuretic peptide and free fatty acid concentration in
normal rats. In 2-kidney 1-clip animals, ketamine did not elicit an
additional response of serum atrial natriuretic peptide or free fatty
acids levels. Its contribution to these factors was not significant.
Συγγραφείς:
Saranteas, T
Zotos, N
Chantzi, C
Mourouzis, C
Rallis, G
and Anagnostopoulou, S
Tesseromatis, C
Περιοδικό:
European Journal of Anaesthesiology
Εκδότης:
Cambridge University Press
Λέξεις-κλειδιά:
atrial natriuretic factor; anaesthetics; intravenous; ketamine; lipids;
fatty acids nonesterified; angiotensins; renin-angiotensin system
DOI:
10.1017/S0265021505001481
