Τίτλος:
Associations between IgG antibody to oral organisms and carotid
intima-medial thickness in community-dwelling adults
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: The aims of this study are to describe the relationships between
IgG antibodies to 17 oral organisms and atherosclerosis as indexed by
carotid intima-medial wall thickness (IMT) and to evaluate the role of
smoking.
Methods and results: Our study is based on a subset of participants in
the Atherosclerosis Risk in Communities (ARIC) Study, who received a
complete periodontal examination during visit 4 (1996-1998). The Outcome
was mean carotid IMT >= 1 mm assessed by B-mode ultrasound. The
exposures were serum IgG antibody levels against 17 periodontal
organisms using a whole bacterial checkerboard immunoblotting technique.
Evaluation of all 17 antibodies indicated that antibody to Campylobacter
rectus resulted in the best-fitting model (OR = 2.3, 95% Cl =
1.83-2.84) and individuals with both high C. rectus and
Peptostreptococcus micros titers had almost twice the prevalence of IMT
>= 1 mm than those with only a high C. rectus antibody (8.3% versus
16.3%). Stratification by smoking indicated that all microbial models
significant for smokers were also significant for never smokers except
for Porphyromonas gingivalis (p = 0.08).
Conclusions: This is the first study to report a relationship between
IgG antibody reactive to oral organisms and subclinical atherosclerosis
with significant relationships evident in both ever and never smokers.
(c) 2005 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Beck, JD
Eke, P
Lin, DM
Madianos, P
Couper, D
Moss,
K
Elter, J
Heiss, G
Offenbacher, S
Περιοδικό:
Atherosclerosis
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
antibodies; atherosclerosis; epidemiology; risk factors; periodontal
disease; smoking
DOI:
10.1016/j.atherosclerosis.2005.03.017
