Τίτλος:
Pseudohyperkalemia in patients with increased cellular components of
blood
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: We performed a study to investigate the difference between
serum and plasma potassium concentration in patients with increase in
one or more of the cellular components of blood. Design and Methods:
This study was performed in two phases. During the first phase, we
performed a cross-sectional comparison of the difference between serum
and plasma potassium concentration (Dk) in 341 patients with the various
clinical conditions where pseuclohyperkalemia has been described, as
well as with secondary or spurious erythrocytosis and in 30 normal
controls. A cut-off value of Dk discriminating polycythemia vera from
other erythrocytoses was estimated. In the second phase we studied the
significance of this cut-off value as predictor of polycythemia vera in
90 naive patients who were referred with an elevated hematocrit.
Results: Dk was significantly increased in the groups with platelet,
erythrocyte or with a mixed type disorder compared to the controls (P <
0.01). Among these groups, Dk was significantly increased in the groups
with thrombocytosis and mixed type disorder, compared to the group with
erythrocytosis (both P < 0.01). A cut-off value of Dk discriminating
polycythemia vera from other erythrocytoses was estimated (0.70 mmol/L).
Dk (>= 0.70 mmol/L), platelet and white blood cell count were identified
as significant independent predictors of polycythemia vera. Conclusions:
The Dk is increased in patients with erythrocytoses, thrombocytoses or
both. This phenomenon is more profound in patients with a mixed type
disorder, such as polycythemia vera patients, compared to those with
erythrocytoses alone.
Συγγραφείς:
Sevastos, N
Theodossiades, G
Savvas, SP
Tsilidis, K and
Efstathiou, S
Archimandritis, AJ
Περιοδικό:
The American Journal of the Medical Sciences
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
pseudohyperkalemia; polycythemia vera; secondary erythrocytoses
DOI:
10.1097/00000441-200601000-00006
