Τίτλος:
Follicle-stimulating hormone receptor gene mutations are not evident in
Greek women with premature ovarian failure and poor responders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aims: This clinical and molecular study aimed to investigate
the presence of follicle-stimulating hormone (FSH) receptor gene
mutations in women with premature ovarian failure (POF) and poor
responders to in vitro fertilization treatment. Methods: DNA was
extracted from blood samples for subsequent polymerase chain reaction
(PCR). PCR was followed by restriction fragment length polymorphism and
direct sequencing. Results: No inactivating mutations reported so far
were identified in exons 6, 7, and 10 in women with POF and poor
responders. Conclusion: FSH receptor gene mutations are not frequent in
Greek patients with POF as is the case in the rest of the world except
for cases with ovarian dysgenesis in Finland. Copyright (C) 2006 S.
Karger AG, Basel.
Συγγραφείς:
Loutradis, D
Patsoula, E
Stefanidis, K
Drakakis, P and
Antonakis, G
Bletsa, R
Antsaklis, A
Michalas, S
Περιοδικό:
Gynecologic and Obstetric Investigation
Λέξεις-κλειδιά:
premature ovarian failure; follicle-stimulating hormone receptor gene;
poor responders; polymerase chain reaction
