Τίτλος:
Correlation between oxidative stress and immunosuppressive therapy in
renal transplant recipients with an uneventful postoperative course and
stable renal function
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Reactive oxygen species (ROS) are important mediators of
cellular damage and lipid peroxidation is the most important expression
of ROS-induced oxidative stress. Recent studies have suggested that
increased plasma malondialdehyde (MDA) levels are a consequence of
specific immunosuppressive therapies. This study aims at investigating
the relation between oxidative stress and immunosuppressive therapies in
renal transplant patients with stable renal function and uneventful
postoperative course.
Methods The study group included 26 renal patients. Two groups of renal
transplant recipients, treated with a different combination of
immunosuppressive agents were studied (Group A: CyA, MMF, Steroids and
Basiliximab, Group B: Tacrolimus, MMF, Steroids and Daclizumab). All
patients had an uneventful postoperative course. Plasma MDA levels were
measured before transplantation, 1 and 6 months after. Plasma
concentration of endogenous creatinine (Cr) was used as a measure of
stable renal function.
Results Levels of MDA were increased before the transplantation in all
renal patients (MDA: 7.81 +/- 4.81, normal levels: 2.23-1.08 nmol/ml, P
< 0.05). Combined therapy with CYA was associated with high values of
MDA at 6 months measurement after transplantation. However this tendency
of increased MDA levels did not achieve a statistical significance
(Group A: 6.97 vs. 9.06 nmol/ml, P > 0.05). On the contrary,
statistically significant diminution of MDA levels was observed in Group
B patients (Tacrolimus-MMF-steroids) at 6 months measurement after
transplantation. (Group B: 8.61 vs. 4.11 nmol/ml, P < 0.02 < 0.05).
Conclusions Immunosuppressive combined therapy with CyA was associated
with the high values of MDA that were measured posttransplantly. Our
study provides strong evidence that Tacrolimus is significantly
associated with improved free radical metabolism.
Συγγραφείς:
Perrea, Despina N.
Moulakakis, Konstantinos G.
Poulakou, Maria
V.
Vlachos, Ioannis S.
Papachristodoulou, Antonios
Kostakis,
Alkiviadis I.
Περιοδικό:
International Urology and Nephrology
Λέξεις-κλειδιά:
renal transplantation; oxidative stress; MDA; immunosuppressive;
Tacrolimus; cyclosporine; reactive oxygen species
DOI:
10.1007/s11255-006-0054-x
