Τίτλος:
Effect of fluconazole antifungal prophylaxis on oral mucositis in head
and neck cancer patients receiving radiotherapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Goal of work: The aim of the study is to evaluate the effect of
fluconazole antifungal prophylaxis on the severity of mucositis in head
and neck cancer patients receiving radiotherapy. Patients and methods:
Sixty-three patients, with malignant head and neck tumor, eligible to
receive radiotherapy, entered the study. Thirty-four patients (group A)
received 100 mg/day of fluconazole prophylaxis during radiotherapy and
were compared with 29 patients, who received radiotherapy alone (group
B). The two groups were similar in terms of patients and radiotherapy
characteristics. Smear to test for Candida carriage was taken before and
after radiotherapy. Oral candidiasis was diagnosed using the criteria
described before. Oral mucositis was recorded according to EORTC/RTOG
criteria. Main results: A significant reduction of severe mucositis at
the end of radiotherapy (14.7 vs 44.8%, p=0.018) and of interruptions
(0 vs 17.2%, p=0.017) was observed in group A. Candidiasis was
prevented (0 vs 34.5%, p=0.001), with a significant reduction of
Candida carriage of 40.7% (p=0.001). Conclusion: Fluconazole
prophylaxis showed a significant beneficial impact on the severity of
mucositis and on radiotherapy interruptions in this group of patients.
The current study provides data on the build of a randomized controlled
trial on the effect of fluconazole prophylaxis on treatment schedule and
quality of life of the patients during head and neck radiotherapy.
Συγγραφείς:
Nicolatou-Galitis, O
Velegraki, A
Sotiropoulou-Lontou, A and
Dardoufas, K
Kouloulias, V
Kyprianou, K
Kolitsi, G and
Skarleas, C
Pissakas, G
Papanicolaou, VS
Kouvaris, J
Περιοδικό:
Supportive Care in Cancer
Λέξεις-κλειδιά:
antifungal prophylaxis; fluconazole; oral candidiasis; oral mucositis;
radiotherapy
DOI:
10.1007/s00520-005-0835-2
