Περίληψη:
Insulin-like growth factor I (IGF-1) stimulates cell proliferation and
can enhance the development of tumours in different organs.
Epidemiological studies have shown that an elevated level of circulating
IGF-1 is associated with increased risk of breast cancer, as well as of
other cancers. Most of circulating IGF-I is bound to an acid-labile
subunit and to one of six insulin-like growth factor binding proteins
(IGFBPs), among which the most important are IGFBP-3 and IGFBP-1.
Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-1
carriers may predict circulating levels of IGF-1 and have an impact on
cancer risk. We tested this hypothesis with a case - control study of
807 breast cancer patients and 1588 matched control subjects, nested
within the European Prospective Investigation into Cancer and Nutrition.
We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1,
IGFBP3 and IGFALS, and measured serum levels of IGF-1 and IGFBP-3 in
samples of cases and controls. We found a weak but significant
association of polymorphisms at the 50 end of the IGF1 gene with breast
cancer risk, particularly among women younger than 55 years, and a
strong association of polymorphisms located in the 50 end of IGFBP3 with
circulating levels of IGFBP-3, which confirms previous findings. Common
genetic variation in these candidate genes does not play a major role in
altering breast cancer risk in Caucasians.
Συγγραφείς:
Canzian, F
McKay, JD
Cleveland, RJ
Dossus, L
Biessy, C
and Rinaldi, S
Landi, S
Boillot, C
Monnier, S
Chajes, V
and Clavel-Chapelon, F
Tehard, B
Chang-Claude, J
Linseisen,
J
Lahmann, PH
Pischon, T
Trichopoulos, D
Trichopoulou, A
and Zilis, D
Palli, D
Tumino, R
Vineis, P
Berrino, F and
Bueno-de-Mesquita, HB
van Gils, CH
Peeters, PHM
Pera, G and
Ardanaz, E
Chirlaque, MD
Quiros, JR
Larranaga, N and
Martinez-Garcia, C
Allen, NE
Key, TJ
Bingham, SA
Khaw,
KT
Slimani, N
Norat, T
Riboli, E
Kaaks, R
