Τίτλος:
Delayed effusive pericarditis and recurrent pleural effusion after
radiation treatment for Hodgkin's disease responsive to per os
doxycycline
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We present our experience with a patient with effusive pericarditis and
recurrent pleural effusion that first developed 23 yr after radiation
treatment for the nodular sclerosis type of Hodgkin’s disease. Extensive
diagnostic work up including pericardial and pleural biopsy, excluded
any other cause (than radiation) of the recurrent pleural effusion.
Pericarditis and pleural effusion were not controlled with regimens
including steroid and non-steroid anti-inflammatory agents. The fluid
collections improved only with per os doxycycline (100 mg twice a day).
Four episodes of recurrent pleural effusions were also controlled with
per os doxycycline. Although the concentration of doxycycline in the
pericardial and pleural fluid when given orally is smaller compared with
that achieved by direct installation of the agent, the fact that all
episodes of pleural effusion improved with an agent commonly used for
pleurodesis is intriguing.
Συγγραφείς:
Fragoulis, KN
Handrinou, E
Papadopoulos, V
Dardoufas, K and
Falagas, ME
Περιοδικό:
European Journal of Haematology
Λέξεις-κλειδιά:
lymphoma; postradiation; sclerosing agent
DOI:
10.1111/j.0902-4441.2005.00577.x
