Τίτλος:
Abnormal auditory N400 in a case of zolpidem dependence, during a
working memory test
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Zolpidem is a GABA (A) agonist, which is indicated for the short-term
management of insomnia. Recent research provide evidence suggesting that
zolpidem produces spatial working memory (WM) deficits and dependence;
however, the underlying mechanisms of these effects are unknown. Since
the auditory N400 component of event-related potentials (ERPS) is
considered as an index of memory use of context processing, the present
study focused on N400 waveform of ERPs elicited during a WM task in a
case suffering from zolpidern dependence. The patterns of N400 waveform
of this case were compared to the patterns obtained from healthy
controls. This comparison revealed that zolpidem dependence is
accompanied by reduced amplitudes located at posterior brain areas and
diffuse prolongation of N400. These findings may indicate that zolpidem
dependence manifests alterations with regard to the memory use of
context processing, involving or affecting a wide-ranging network of the
brain’s structures. (c) 2005 Elsevier SAS. All rights reserved.
Συγγραφείς:
Liappas, IA
Papageorgiou, CC
Rabavilas, AD
Περιοδικό:
European Psychiatry
Εκδότης:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Λέξεις-κλειδιά:
auditory N400; dependence; event-related potentials; working memory;
zolpidem
DOI:
10.1016/j.eurpsy.2004.11.013
