Τίτλος:
QT dispersion: Comparison between participants with type 1 and 2
diabetes and association with microalbuminuria in diabetes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: The interlead variation of QT duration ill Surface
electrocardiogram [ECG; QT dispersion (QTd)] has been shown to predict
mortality in both diabetic and general population. Diabetic cardiac
autonomic neuropathy (CAN) is a common complication of diabetes, and it
is also associated with worse prognosis among the diabetic population.
In this study, we investigated the association between QTd duration and
CAN, as well as other complications of diabetes in participants with
Types 1 and 2 diabetes. Methods: A total of 184 patients with either
Type 1 (n=63) or 2 (n=121) diabetes, as well as 100 control
participants, matched for age and sex with the diabetic individuals,
were studied. QT and RR intervals were measured on 12 leads of resting
ECG tracing. QTd was calculated semiautomatically using a computer
program as the difference between the maximum and the Minimum QT in any
of the 12 leads. CAN was diagnosed when two out of the four classical
tests were abnormal. Results: QTd was not significantly different
between controls and patients with either Type 1 or 2 diabetes.
Age-adjusted QTd intervals were not significantly different between
patients with Types 1 and 2 diabetes (P=.86). For both types of
diabetes, no significant differences were found in QTd between patients
with and without CAN. Multivariable linear regression analysis, after
adjustment for a number of confounding factors, demonstrated a positive
association between QTd and duration of diabetes (P=.02) in the group of
the patients with Type 1 diabetes. In those with Type 2 diabetes, QTd
was associated with age (P=.006) and presence of microalbuminuria
(P=.001). In addition, no significant association was found with
retinopathy or blood pressure levels. Conclusions: Age-adjusted QTd
interval was not different between patients with Types 1 and 2 diabetes.
CAN is not associated with QTd interval in both types of diabetes.
Furthermore, inicroalbuminuria was found to be the strongest predictor
of QTd in patients with Type 2 diabetes. Because long QTd interval
predicts cardiac mortality in participants with diabetes, it is
suggested that it may be a useful adjuvant index in the evaluation of
cardiovascular risk in participants with Type 2 diabetes and
microalbuminuria. (c) 2006 Elsevier Inc. All rights reserved.
Συγγραφείς:
Psallas, M
Tentolouris, N
Papadogiannis, D
Doulgerakis, D
and Kokkinos, A
Cokkinos, DV
Katsilambros, N
Περιοδικό:
Journal of Diabetes and its Complications
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
QT interval; QT dispersion; diabetes mellitus; cardiac autonomic
neuropathy; microalbuminuria
DOI:
10.1016/j.jdiacomp.2005.05.012
