Περίληψη:
We investigated in detail the difference between serum and plasma
potassium levels in patients with several conditions associated with
pseudohyperkalemia. In total, 435 patients with either thrombocytoses,
erythrocytoses, leucocytoses, or a mixed-type disorder and 30 healthy
controls were included. In each case, the index Dk (serum potassium
minus plasma potassium) and the index Dk100 (Dk x 100,000/platelets),
which indicates the Dk value that corresponds to platelets of
100,000/mm(3) were estimated. Median Dk was significantly higher in the
groups with platelet, erythrocyte, or mixed-type disorders than in the
controls (P = 0.001). Among these groups, Dk values were significantly
higher in patients with thrombocytosis or mixed-type disorders compared
with those with erythrocytosis (P < 0.001, for both). Furthermore, no
significant difference was observed in Dk values between controls and
patients with white blood cell disorders (P = 0.74). Dk values did not
exceed 2.61 mmol/L, whereas Dk100 values were inversely related to
platelet counts (r = - 0.351, P < 0.01). In conclusion,
pseudohyperkalemia is mainly present in patients with thrombocytosis or
mixed-type disorders, probably as a result of the degranulation of
platelets, which offers a potassium load to the surrounding plasma at
the time of clot formation in vitro. However, the degree of
pseudohyperkalemia does not increase proportionally with the increase of
platelet counts, which may be associated with transfer of part of
potassium load from the plasma back into red and white blood cells.
Συγγραφείς:
Sevastos, N
Theodossiades, G
Efstathiou, S
Papatheodoridis,
GV
Manesis, E
Archimandritis, AJ
