Περίληψη:
Tobacco smoking is the only established risk factor for pancreatic
cancer. Results from several epidemiologic studies have suggested that
increased body mass index and/or lack of physical activity may be
associated with an increased risk of this disease. We examined the
relationship between anthropometry and physical activity recorded at
baseline and the risk of pancreatic cancer in the European Prospective
Investigation into Cancer and Nutrition (n = 438,405 males and females
age 19-84 years and followed for a total of 2,826,070 person-years).
Relative risks (RR) were calculated using Cox proportional hazards
models stratified by age, sex, and country and adjusted for smoking and
self-reported diabetes and, where appropriate, height. In total, there
were 324 incident cases of pancreatic cancer diagnosed in the cohort
over an average of 6 years of follow-up. There was evidence that the RR
of pancreatic cancer was associated with increased height [RR, 1.74;
95% confidence interval (95% CI), 1.20-2.52] for highest quartile
compared with lowest quartile (P-trend = 0.001). However, this trend was
primarily due to a low risk in the lowest quartile, as when this group
was excluded, the trend was no longer statistically significant (P =
0.27). A larger waist-to-hip ratio and waist circumference were both
associated with an increased risk of developing the disease (RR per 0.1,
1.24; 95% CI, 1.04-1.48; P-trend = 0.02 and RR per 10 cm, 1.13; 95%
CI, 1.01-1.26; P-trend = 0.03, respectively). There was a nonsignificant
increased risk of pancreatic cancer with increasing body mass index (RR,
1.09; 95% CI, 0.95-1.24 per 5 kg/m(2)), and a nonsignificant decreased
risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most
active versus inactive). Future studies should consider including
measurements of waist and hip circumference, to further investigate the
relationship between central adiposity and the risk of pancreatic
cancer.
Συγγραφείς:
de Gonzalez, Amy Berrington
Spencer, Elizabeth A. and
Bueno-de-Mesquita, H. Bas
Roddam, Andrew
Stolzenberg-Solomon,
Rachel
Halkjaer, Jytte
Tjonneland, Anne
Overvad, Kim and
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine and
Boeing, Heiner
Pischon, Tobias
Linseisen, Jakob
Rohrmann,
Sabine
Trichopoulou, Antonia
Benetou, Vassiliki and
Papadimitriou, Aristoteles
Pala, Valeria
Palli, Domenico and
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Boshuizen,
Hendriek C.
Ocke, Marga C.
Peeters, Petra H.
Lund, Eiliv and
Gonzalez, Carlos A.
Larranaga, Nerea
Martinez-Garcia, Carmen and
Mendez, Michelle
Navarro, Carmen
Quiros, J. Ramon
Tormo,
Maria-Jose
Hallmans, Goran
Ye, Weimin
Bingham, Sheila A. and
Khaw, Kay-Tee
Allen, Naomi
Key, Tim J.
Jenab, Mazda and
Norat, Teresa
Ferrari, Pietro
Riboli, Elio
