Περίληψη:
Blood concentrations of insulin-like growth factor-I (IGF-I) and
insulin-like growth factor binding protein-3 (IGFBP-3) have recently
been associated with breast cancer risk, notably in women who developed
breast cancer at a young age. Prospective studies published so far,
however, were relatively small and odds ratio (OR) estimates imprecise.
We present the results of a large prospective case-control study nested
within the European Prospective Investigation into Cancer and Nutrition
on total IGIF-I, IGFBP-3 and breast cancer risk including 1081 incident
cases of invasive breast cancer and 2098 matched control subjects.
Increasing IGF-I and IGFBP-3 concentrations were associated with a
significant increase in breast cancer risk in women who developed breast
cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95%
confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI
1.04-1.98), P = 0.01, respectively), but no relationship was observed in
younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR
= 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however,
significant heterogeneity in the relationship of breast cancer with
serum IGF-I and IGFBP-3 levels depending on the time interval between
blood donation and tumor diagnosis. A reduction in breast cancer risk
with increasing IGF-I concentrations was observed in cases with a
diagnosis of cancer less than 2 years after blood donation, (OR = 0.76
(95% CI 0.57-1.03)), while an increase in risk was observed for women
with a later diagnosis (above or equal to two years after blood
collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was
observed for IGFBP-3. This study confirms previous findings for an
association of serum IGF-I and IGFBP-3 concentrations with breast cancer
risk, particularly for women with a later diagnosis of cancer, but it
does not support the hypothesis of an involvement of IGF-I in younger
women.
Συγγραφείς:
Rinaldi, S.
Peeters, P. H. M.
Berrino, F.
Dossus, L. and
Biessy, C.
Olsen, A.
Tjonneland, A.
Overvad, K. and
Clavel-Chapelon, F.
Boutron-Ruault, M. C.
Tehard, B.
Nagel,
G.
Linseisen, J.
Boeing, H.
Lahmann, P. H.
Trichopoulou,
A.
Trichopoulos, D.
Koliva, M.
Palli, D.
Panico, S. and
Tumino, R.
Sacerdote, C.
van Gils, C. H.
van Noord, P. and
Grobbee, D. E.
Bueno-de-Mesquita, H. B.
Gonzalez, C. A. and
Agudo, A.
Chirlaque, M. D.
Barricarte, A.
Larranaga, N. and
Quiros, J. R.
Bingham, S.
Khaw, K. T.
Key, T.
Allen, N.
E.
Lukanova, A.
Slimani, N.
Saracci, R.
Riboli, E. and
Kaaks, R.
